Evidence map›Paper›PMID 41180957›Full record

ArticleJournal of Alzheimer's disease reports

Vitreous STMN2 levels reflect TDP-43-associated neurodegeneration in postmortem eyes and brains.

Surya V Pulukuri, Elizabeth E Spurlock, Fatima Tuz-Zahra, Yorghos Tripodis, Konstantina Sampani, Raymond Nicks, Gaoyuan Meng, Victor E Alvarez, Ann C McKee, Weiming Xia and 3 more

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Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Surya V PulukuriHarvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-0751-0201
Elizabeth E SpurlockAlzheimer's Disease Research Center and CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Fatima Tuz-ZahraDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Yorghos TripodisAlzheimer's Disease Research Center and CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Konstantina SampaniBeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.ORCID https://orcid.org/0000-0002-6570-328X
Raymond NicksAlzheimer's Disease Research Center and CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Gaoyuan MengGeriatric Research Education and Clinical Center, VA Bedford Healthcare System, Bedford, MA, USA.
Victor E AlvarezAlzheimer's Disease Research Center and CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Ann C McKeeAlzheimer's Disease Research Center and CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Weiming XiaAlzheimer's Disease Research Center and CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.ORCID https://orcid.org/0000-0002-7463-3295
Daniel A MordesInstitute for Neurodegenerative Diseases, University of California, San Francisco, CA, USA.
Manju L SubramanianDepartment of Ophthalmology, Boston Medical Center, Boston, MA, USA.
Thor D SteinAlzheimer's Disease Research Center and CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.ORCID https://orcid.org/0000-0001-6954-4477

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stathmin-2 (STMN2) levels decline in brains with transactive response DNA binding protein-43 (TDP-43) inclusions. TDP-43-related changes could extend to ocular structures, although vitreous STMN2 levels remain uncharacterized. This exploratory study analyzed 72 post-mortem brains and eyes depending on the presence or absence of TDP-43 inclusions in the brain and across neuropathological diagnostic groups (Alzheimer's disease [AD], chronic traumatic encephalopathy [CTE], AD and CTE, or neither). Results showed decreased vitreous STMN2 levels in TDP-43-positive cases but no association with diagnostic groups. Vitreous STMN2 was correlated with vitreous neurofilament light chain. Diminished vitreous STMN2 levels might indicate TDP-43-associated neurodegeneration.

Indexed as

Alzheimer's diseasechronic traumatic encephalopathyTDP-43vitreous biomarkers

Identifiers

PMID41180957
PMCPMC12576212

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.