Evidence map›Paper›PMID 41180812›Full record

ArticleFrontiers in aging neuroscience2025

Mediating role of brain aging in the effect of white matter hyperintensities on post-stroke aphasia severity.

Guihua Xu, Yongsheng Wu, Rui Zhu, Junyu Qu, Wenwen Xu, Jiaxiang Xin, Dawei Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Accelerated brain aging and anterior white matter hyperintensity burden in chronic post-stroke aphasia: a lesion-aware MRI analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guihua XuDepartment of Radiology, Qilu Hospital of Shandong University and Qilu Medical Imaging Institute of Shandong University, Jinan, China.
Yongsheng WuDepartment of Radiology, Qilu Hospital of Shandong University and Qilu Medical Imaging Institute of Shandong University, Jinan, China.
Rui ZhuDepartment of Radiology, Qilu Hospital of Shandong University and Qilu Medical Imaging Institute of Shandong University, Jinan, China.
Junyu QuDepartment of Radiology, Qilu Hospital of Shandong University and Qilu Medical Imaging Institute of Shandong University, Jinan, China.
Wenwen XuDepartment of Radiology, Qilu Hospital of Shandong University and Qilu Medical Imaging Institute of Shandong University, Jinan, China.
Jiaxiang XinMR Research Collaboration, Siemens Healthineers Ltd., Shanghai, China.
Dawei WangDepartment of Radiology, Qilu Hospital of Shandong University and Qilu Medical Imaging Institute of Shandong University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: White matter hyperintensities (WMH) have been associated with the severity of post-stroke aphasia (PSA), but the contribution of overall brain health remains unclear. Brain age is a neurobiological indicator of aging that is based on whole-brain structural neuroimaging. This study investigated the impact of brain age on language function after stroke. Methods: Fifty-seven patients with PSA and left-hemisphere lesions were included. The Fazekas scale was used to evaluate WMH burden, including periventricular WMH (PWMH) and deep WMH (DWMH). Brain age was estimated using structural 3D T1-weighted imaging, and the Brain-Predicted Age Difference (brain-PAD) was calculated. Multivariate linear regression and mediation analysis were conducted to examine associations among WMH burden, brain-PAD, and aphasia severity. The interaction between WMH burden and brain-PAD was also assessed. Results: Higher levels of PWMH and DWMH were associated with increased brain-PAD in PSA patients (PWMH: Conclusion: Our findings highlight the influence of neuroanatomical aging and WMH burden on post-stroke language deficits, supporting the consideration of both brain-PAD and WMH severity when assessing aphasia severity to inform clinical assessment and treatment planning.

Indexed as

brain ageinteraction analysismediation analysispost-stroke aphasiawhite matter hyperintensities

Identifiers

PMID41180812
PMCPMC12571856

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.