ReviewAnnals of medicine and surgery (2012)2025
Trends in multiple myeloma and cardiovascular disease-related mortality among older adults in the United States, 1999 to 2023: a CDC wonder database analysis.
Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Trends in mortality rates associated with multiple myeloma in the United States, 1999-2023.Frontiers in oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Multiple myeloma (MM) is highly associated with cardiovascular complications, and their co-existence significantly increases the risk of cardiovascular events and mortality, predominantly in older adults. Therefore, we aim to analyze MM and cardiovascular disease (CVD) mortality trends in older adults from 1999 to 2023 in the United States (U.S). Methods: A retrospective analysis of Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database was conducted from 1999 to 2023, including death records of adults (aged 65 ≤) with MM and CVDs. Age-adjusted mortality rates (AAMR) per 100,000 population and annual percent changes (APC) in AAMRs were calculated and measured across different demographics and geographies in the U.S. Results: MM and CVD have caused a total of 99,637 deaths. AAMR increased from 9.6 in 1999 to 9.9 in 2023, with a prominent surge noted between 2018 and 2021 (APC: 6.82). Males (12.5) had almost double the AAMR that of females (7.0), while the AAMR of 18.6 was seen in NH African Americans, triple that of other races/ethnicities. Geographically, AAMR was higher in metropolitan areas (9.2) and the Northeast region (10.1). Conclusions: Proper resource distribution and more targeted interventions are needed to address the rising trends in MM and CVD-associated mortality across different geographic and demographic groups.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.