ArticleAnnals of medicine and surgery (2012)2025
Trends in chronic kidney disease-related mortality in older adults in the United States from 1999 to 2020: a cross-sectional study.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Mortality trends involving chronic kidney disease and electrolyte and acid-base disorders in the United States, 1999-2023: a CDC WONDER analysis.Annals of medicine and surgery (2012) · 2026Article
- Twenty-six-year trends in U.S. mortality among older adults with coexisting chronic kidney disease and atrial fibrillation/flutter.Annals of medicine and surgery (2012) · 2026Review
- Trends in Anemia and Kidney Failure Related Mortality (1999-2023): A 25-Year Retrospective Analysis.Journal of immigrant and minority health · 2026Article
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Authors and funding
15 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic kidney disease (CKD) is becoming increasingly common in the United States, particularly among older adults. However, little is known about the mortality patterns within this demographic. Objective: This study aims to explore the demographic and regional patterns of CKD-associated mortality in the United States from 1999 to 2020 among adults >65 years old. Methods: The Centers for Disease Control and Prevention's WONDER (Wide-Ranging Online Data for Epidemiologic Research) database's death certificates were analyzed for CKD-related mortality in persons aged 65 and older between 1999 and 2020. Age-adjusted mortality rates (AAMRs) per 10 000 and annual percentage change were calculated, stratified by geographic region, sex, year, and race/ethnicity. Results: Between 1999 and 2020, 1 572 075 CKD-related deaths occurred among adults ≥65 years. AAMR increased significantly from 132.0 in 1999 to 216.6 in 2020. Men consistently had higher AAMRs than women. Non-Hispanic (NH) Black has the highest AAMR (312.3), followed by NH American Indian (188.8), Hispanic (178), NH White (157), and NH Asian (143.9). Additionally, there was significant regional heterogeneity in AAMR (Midwest 184.6; South: 171.6; West: 165.5; Northeast: 157.4), with CKD-related AAMR being greater in non-metropolitan areas. States with CKD-related rates in the top 90th percentile AAMR were West Virginia, North Dakota, Indiana, Ohio, South Carolina, and North Carolina. Conclusions: CKD-related mortality in US adults ≥65 years has increased from 1999 to 2020. The highest AAMRs were noticed among NH Blacks, men, and patients residing in non-metropolitan and Midwestern areas of the United States. A targeted approach is required to significantly decrease the mortality in this population group.
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