ArticleTzu chi medical journal
Protective effects of 7-hydroxyflavone on mitochondrial membrane potential and hydrogen peroxide-induced apoptosis in cardiomyocytes.
Article in Tzu chi medical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Objectives: The objective is to evaluate the protective effects of six coumarin derivatives against peroxide-induced cardiomyocyte damage and investigate their action mechanisms. Materials and Methods: Intracellular reactive oxygen species and mitochondrial membrane potential (MMP) were analyzed using dihydrorhodamine 123 and JC-1 combined with flow cytometry. Cell viability and apoptosis were assessed using WST-1 and lactate dehydrogenase analysis kits, respectively. The apoptotic signaling pathway was analyzed using a mouse apoptosis array kit. Cellular protein expression was detected using Western blotting. Results: Among the six coumarin derivatives tested, only 7-hydroxyflavone demonstrated the ability to protect cardiomyocytes from hydrogen peroxide (H Conclusion: 7-hydroxyflavone has potential as an effective antioxidant supplement for cardiac tissues. Further research is required to elucidate its pharmacokinetics and metabolic profile in humans to facilitate its therapeutic application.
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