Evidence map›Paper›PMID 41180456›Full record

ArticleFrontiers in molecular biosciences2025

Impact of endurance training on mitochondrial H

Lukasz Galganski, Krzysztof Wojcicki, Wieslawa Jarmuszkiewicz, Jerzy A Zoladz

Abstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Update: Is exercise-induced oxidative stress a friend or foe?Sports medicine and health science · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lukasz GalganskiMitochondrial Biochemistry Research Group, Faculty of Biology, Adam Mickiewicz University in Poznan, Poznań, Poland.
Krzysztof WojcickiMitochondrial Biochemistry Research Group, Faculty of Biology, Adam Mickiewicz University in Poznan, Poznań, Poland.
Wieslawa JarmuszkiewiczMitochondrial Biochemistry Research Group, Faculty of Biology, Adam Mickiewicz University in Poznan, Poznań, Poland.
Jerzy A ZoladzChair of Exercise Physiology and Muscle Bioenergetics, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In recent years, increasing attention has focused on the effect of exercise on redox balance and the expression of nuclear factor erythroid 2-related factor 2 (NRF2), widely recognized as the master regulator of antioxidant defense mechanisms. However, surprisingly little is known about how physical training influences H Methods: We investigated the effects of endurance training on the oxidative capacity, reactive oxygen species production, and antioxidant defense of various body organs in rats. Sixteen 4-month-old male Wistar rats were randomly assigned to either an endurance training group (8 weeks of treadmill running, Results: In the endurance training group, maximal oxidative activity increased in all examined tissues (lung, brain, liver, and hind limb skeletal muscle) except the heart. Under phosphorylating conditions, H Conclusion: Given the cytoprotective capacity of NRF2, we postulate that the NRF2-regulated adaptive multi-organ response may play a key role in the widely described beneficial effects of physical activity on various body organs and body health.

Indexed as

endurance trainingmitochondrial ROS formationmulti-organ adaptive responseNRF2oxidative stress

Identifiers

PMID41180456
PMCPMC12571570

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.