ArticleF1000Research2025
Alpha-guaiene isolated from patchouli oil exhibits antifungal activity against four pathogenic fungi.
Article in F1000Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Antibacterial, In Vitro Anti-Inflammatory and Anti-Acne Activities ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Hybrid function of light fraction patchouli oil in hair care formulations for effective hair and anti-dandruff treatment.Narra J · 2025Article
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Authors and funding
5 authors.
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Abstract
Background: The major component of patchouli oil, patchouli alcohol, is used as fixative and has antimicrobial activity. The function of other components, such as α-guaiene, remains unknown. Therefore, this study reports the antifungal activity of α-guaiene isolated from patchouli oil against for pathogenic fungi: Methods: The material from fraction (249°C-254°C) had the highest α-guaiene. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined using the microdilution technique to evaluate antifungal activity, with n-hexane and medium serving as negative controls, and ketoconazole and fluconazole serving as positive controls. Results: The results showed that the MIC and MFC value were determined at 45%, 50% for Conclusions: Overall, this study reveals that α-guaiene is a promising agent effective against the studied pathogenic fungi.
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