Evidence map›Paper›PMID 41180393›Full record

ArticleEJHaem2025

T-Cell-Replete Haploidentical Hematopoietic Stem Cell Transplantation for Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia After CAR-T Therapy.

Nobuhisa Takahashi, Kazuhiro Mochizuki, Tomoko Waragai, Shingo Kudo, Yui Sasaki, Atsushi Kikuta, Hitoshi Ohto, Kazuhiko Ikeda, Hideki Sano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nobuhisa TakahashiDepartment of Pediatric Oncology Fukushima Medical University Fukushima Japan.
Kazuhiro MochizukiDepartment of Pediatric Oncology Fukushima Medical University Fukushima Japan.
Tomoko WaragaiDepartment of Pediatric Oncology Fukushima Medical University Fukushima Japan.
Shingo KudoDepartment of Pediatric Oncology Fukushima Medical University Fukushima Japan.
Yui SasakiDepartment of Pediatric Oncology Fukushima Medical University Fukushima Japan.
Atsushi KikutaDepartment of Pediatric Oncology Fukushima Medical University Fukushima Japan.
Hitoshi OhtoDepartment of Blood Transfusion and Transplantation Immunology Fukushima Medical University Fukushima Japan.
Kazuhiko IkedaDepartment of Blood Transfusion and Transplantation Immunology Fukushima Medical University Fukushima Japan.
Hideki SanoDepartment of Pediatric Oncology Fukushima Medical University Fukushima Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent acute lymphoblastic leukemia (ALL) following chimeric antigen receptor T-cell (CAR-T) therapy represents a significant therapeutic challenge, particularly in pediatric populations. This report describes three cases of B-cell precursor ALL that recurred after CAR-T therapy and were successfully treated with T-cell-replete haploidentical hematopoietic stem cell transplantation (TCR-haplo-HSCT). This approach has shown promising outcomes in terms of long-term survival, highlighting the potential of TCR-haplo-HSCT as consolidation therapy for recurrent pediatric ALL post-CAR-T therapy.

Indexed as

acute lymphoblastic leukemiablinatumomabchimeric antigen receptor T‐cell therapygraft‐versus‐host diseasehematopoietic stem cell transplantation

Identifiers

PMID41180393
PMCPMC12573471

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.