ArticleEJHaem2025
Factors Associated with Risk of Clonal Haematopoiesis of Indeterminate Potential: A Systematic Review and Meta-Analysis.
Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Clonal hematopoiesis of indeterminate potential and metabolic dysfunction-associated steatotic liver disease: Korean biopsy cohort.Hepatology international · 2026Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Clonal haematopoiesis of indeterminate potential (CHIP) is a risk factor for blood cancers and non-haematological diseases. Understanding factors that lead to CHIP is essential in developing preventive strategies. We aimed to identify factors associated with risk of CHIP through a systemic literature review. Methods: We searched MEDLINE and EMBASE for original studies reporting an age-adjusted risk measure for factors associated with an outcome of incident or prevalent CHIP. Random effects meta-analyses were performed for factors reported in at least three cohorts. Results: From 3305 abstracts, 26 studies were included, ranging from 118 to 239,216 participants. Risk of CHIP was higher in those with hypertension (Odds Ratio [OR] 1.1, 95% confidence interval 1.03-1.16), HIV infection (OR 2.37; 1.68-3.34), and smoking (OR 1.13; 1.10-1.17). The risk of CHIP was lower in those of Asian compared to White ethnicity (OR 0.73; 0.56-0.94). Male sex was not associated with risk of CHIP overall (OR 0.94; 0.86-1.03), but was associated with reduced risk of Conclusion: Our findings highlight the heterogeneity of CHIP, and suggest that factors associated with risk of CHIP differ between genes. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.
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