Evidence map›Paper›PMID 41180368›Full record

ArticleAPL bioengineering2025

Enhanced photo-sono therapy with dual-frequency ultrasound.

Yuchen Song, Shuang Wei, Haibin Zou, Jingyi Wang, Fengyi Zhang, Qifa Zhou, Yun Jing, Zhongping Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in APL bioengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuchen SongORCID https://orcid.org/0000-0002-3581-0172
Shuang WeiORCID https://orcid.org/0009-0001-4305-9980
Haibin ZouBeckman Laser Institute, University of California Irvine, Irvine, California 92612, USA.ORCID https://orcid.org/0009-0000-3851-1023
Jingyi WangORCID https://orcid.org/0000-0002-8722-2401
Fengyi ZhangORCID https://orcid.org/0009-0009-3785-2630
Qifa ZhouDepartment of Biomedical Engineering, University of Southern California, Los Angeles, California 90089, USA.ORCID https://orcid.org/0000-0003-1527-3020
Yun JingGraduate Program in Acoustics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.ORCID https://orcid.org/0000-0003-2960-5292
Zhongping ChenORCID https://orcid.org/0000-0002-4584-4560

Funding

Phase resolved ARF optical coherence elastography for intravascular imagingR01HL125084 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ZHOU, QIFA · 2014 to 2023
$5.6M
Breaking the Scattering Barrier: Multimodal Non-invasive Deep Tissue Imaging Using Reflection Matrix Based Wavefront ShapingUG3DA065120 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, HU, SONG · 2025 to 2025
$3.0M
Combined OCT/US/PAT system for intravascular ImagingR01HL127271 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, PATEL, PRANAV · 2015 to 2018
$2.7M
High-resolution Elastographic Assessment of the Optic Nerve HeadR01EY028662 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, SIGAL, IAN A · 2018 to 2021
$2.7M
In vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging TechnologyR01EB030024 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, WONG, BRIAN · 2020 to 2024
$2.3M
Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA EndoscopyR01EB030558 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, LANE, FELICIA LUCIA · 2021 to 2021
$1.9M
NEI NIH HHS R01 EY028662NHLBI NIH HHS R01 HL125084NHLBI NIH HHS R01 HL127271NIBIB NIH HHS R01 EB030024NIBIB NIH HHS R01 EB030558NIDA NIH HHS UG3 DA065120
6 · The paper itself

Abstract

Photo-sono therapy (PST) is a cavitation-based anti-vascular and thrombolysis treatment strategy. Compared to conventional high intensity focused ultrasound treatment, PST can selectively treat blood vessels and clots because of optical absorption. Current methods typically combine a single-frequency ultrasound burst with pulse laser irradiation. However, the high acoustic energy required and limited treatment efficacy present a barrier to the clinical application of this technique. In this paper, we introduce a dual-frequency ultrasound approach to enhance PST efficacy with reduced acoustic energy. Through both theoretical bubble dynamics modeling and experimental study, the effect of dual-frequency ultrasound in PST is evaluated. The feasibility of the proposed method was validated using

Identifiers

PMID41180368
PMCPMC12578473

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.