Evidence map›Paper›PMID 41180232›Full record

ArticleFrontiers in veterinary science2025

Genome-centric investigation of bile acid-metabolizing microbiota in chickens and their association with

Kai-Meng Shang, Hany M Elsheikha, Yong-Jie Wei, Xiao-Xuan Zhang, Xin-Wen Hou, Hai-Long Yu, Yanan Cai, Hong-Bo Ni, Rui Liu, He Ma and 3 more

Abstract read
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Applied and environmental microbiology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kai-Meng Shang *Integrated Laboratory of Pathogenic Biology, College of Preclinical Medicine, Dali University, Dali, China.
Hany M Elsheikha *Faculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, University of Nottingham, Loughborough, United Kingdom.
Yong-Jie Wei *College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong, China.
Xiao-Xuan ZhangCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong, China.
Xin-Wen HouCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong, China.
Hai-Long YuCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong, China.
Yanan CaiCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, Jilin, China.
Hong-Bo NiCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong, China.
Rui LiuCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong, China.
He MaCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong, China.
Jing JiangCollege of Life Sciences, Changchun Sci-Tech University, Shuangyang, Jilin Province, China.
Fulong NanCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong, China.
Xing YangIntegrated Laboratory of Pathogenic Biology, College of Preclinical Medicine, Dali University, Dali, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Bile acid (BA) metabolism by gut microbiota plays a crucial role in host health by influencing nutrient absorption, immune responses, and resistance to pathogens. Elucidating how enteric infections disrupt the BA-microbiota axis is crucial for advancing microbiota-based therapeutics, precision nutrition, and post-antibiotic disease control strategies. Methods: We reconstructed 9,990 high-quality microbial genomes from the gut microbiota of chicken and performed genome-resolved metabolic profiling. Comparative analyses were conducted across host species, including humans and pigs. Also, 135 intestinal samples collected from different regions of the chicken gut were analyzed. Additional samples from chickens infected with Salmonella typhimurium and Eimeria tenella were included to assess infection-associated alterations. Results: Our results reveal that the phylum Discussion: Together, these findings advance our understanding of microbial contributions to BA dynamics in poultry and offer insights into the role of BA metabolism in gut health and pathogen resistance.

Indexed as

bile acid metabolismchickenEimeria tenellagut microbiotaSalmonella typhimurium

Identifiers

PMID41180232
PMCPMC12575232

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.