Evidence map›Paper›PMID 41180231›Full record

ArticleFrontiers in veterinary science2025

Seneca valley virus VP4 protein regulates the transcription of different cytokines

Chaoliang Leng, Yu Ge, Mengfan Ruan, Wenxiao Zhao, Ximei Yang, Sainan Gao, Hongyue Zhai, Dandan Li, Dan Rao, Jianguo Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chaoliang LengHenan Key Laboratory of Insect Biology, Henan Provincial Engineering and Technology Center of Animal Disease Diagnosis and Integrated Control, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, China.
Yu GeSchool of Animal Husbandry and Veterinary Medicine Engineering, Xinyang Agriculture and Forestry University, Xinyang, China.
Mengfan RuanSchool of Animal Husbandry and Veterinary Medicine Engineering, Xinyang Agriculture and Forestry University, Xinyang, China.
Wenxiao ZhaoSchool of Animal Husbandry and Veterinary Medicine Engineering, Xinyang Agriculture and Forestry University, Xinyang, China.
Ximei YangSchool of Animal Husbandry and Veterinary Medicine Engineering, Xinyang Agriculture and Forestry University, Xinyang, China.
Sainan GaoAnLing Biopharmaceutical (Suzhou) Co., Ltd, Suzhou, China.
Hongyue ZhaiHenan Key Laboratory of Insect Biology, Henan Provincial Engineering and Technology Center of Animal Disease Diagnosis and Integrated Control, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, China.
Dandan LiHenan Key Laboratory of Insect Biology, Henan Provincial Engineering and Technology Center of Animal Disease Diagnosis and Integrated Control, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, China.
Dan RaoSchool of Animal Husbandry and Veterinary Medicine Engineering, Xinyang Agriculture and Forestry University, Xinyang, China.
Jianguo DongSchool of Animal Husbandry and Veterinary Medicine Engineering, Xinyang Agriculture and Forestry University, Xinyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To understand the effect of Seneca valley virus (SVV) VP4 protein on innate immune factors, the VP4 gene was cloned into the pEGFP-C1 expression plasmid to construct the pEGFP-C1-VP4 recombinant plasmid. After the recombinant plasmid was transfected into 293 T cells, the cell fluid was collected 24 h after transfection for western blot assay to identify the correctness of VP4 protein expression. Cell culture medium was collected from un-transfected and transfected cells at three time points (12, 24, and 36 h). mRNA expression levels of cytokines (IL-1

Indexed as

chemokineeukaryotic expressioninterleukinSeneca valley virustumornecrosis factorVP4 protein

Identifiers

PMID41180231
PMCPMC12571611

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.