Trial reportFrontiers in endocrinology2025
The anti-inflammatory effects of dexamethasone implants in eyes with heavy silicone oil: a prospective study on vitrectomy for diabetic retinopathy.
Trial report in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
9 authors.
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Abstract
Purpose: This study aims to assess the effects of heavy silicone oil (HSO) tamponade in patients with diabetic tractional retinal detachment (TRD) treated with pars plana vitrectomy (PPV), and to evaluate the role of extended-release hormone implantation in controlling inflammation and mitigating postoperative complications. Methods: A prospective, randomized, controlled design was used in this study. This study included 96 eyes from 96 patients diagnosed with diabetic TRD, all of whom were treated at our institution between March 2024 and March 2025. Group 1 consisted of 54 eyes from 54 patients (PPV + HSO + dexamethasone implant), while Group 2 included 42 eyes from 42 patients (PPV + HSO). The primary outcomes included best-corrected visual acuity (BCVA), intraocular pressure (IOP), retinal reattachment rate, anterior chamber (AC) fibrin exudation, anterior proliferative vitreoretinopathy (PVR), and posterior iris synechiae during the 3-month postoperative follow-up period. Results: Eighty eyes from 80 patients were ultimately included in the study, with 40 eyes assigned to each group. Patient characteristics, including age, sex, preoperative HbA1c levels and preoperative blood pressure,DR severity were similar ( Conclusion: To our knowledge, this first study of dexamethasone implants with HSO in PDR suggests intraoperative DEX may be a safe, potentially beneficial adjunct for diabetic TRD undergoing phacoemulsification plus vitrectomy with HSO, reducing inflammation and number of anti-VEGF injections over 3 months, and offering useful directions for future research in this preliminary prospective evaluation overall.
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