SynthesisFrontiers in endocrinology2025
FSH priming and hormonal modulation of oocyte competence in
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Does follicle-stimulating hormone priming improve reproductive outcomes in women undergoing Objective: To evaluate the effects of FSH priming on oocyte maturation and reproductive potential in IVM cycles for infertile women. Methods: Employing PRISMA guidelines, we systematically searched PubMed, Cochrane Library, Embase, and Web of Science for randomized controlled trials comparing FSH-primed versus non-primed IVM cycles in infertile women. The primary outcome was oocyte maturation rate, whereas secondary outcomes included fertilization rate, cleavage rate, pregnancy rate, and implantation rate. Data pooled used random-effects models, with heterogeneity assessed by Results: Six randomized controlled trials comprising of 497 women were analyzed. FSH priming was associated with a statistically significant increase in oocyte maturation rate [OR 1.24(95% CI, 1.05-1.45)] when compared with the non-stimulated group. However, pooled analysis showed no significant differences in fertilization rate or clinical pregnancy rate between groups. Conclusion: FSH priming has been shown to enhance oocyte maturation rate in
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