Evidence map›Paper›PMID 41180175›Full record

ArticleFrontiers in endocrinology2025

Distinct complication profiles: a comparative study of Ethiopian and non-Ethiopian adults with type 1 diabetes.

Alena Kirzhner, Amir Bashkin, Hefziba Green, Haitham Abu Khadija, Shay Teitlboim, Meital Zikry Deitch, Mohammad Alnees, Merav Greenstein, Tal Schiller

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alena KirzhnerDepartment of Internal Medicine A, Kaplan Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Amir BashkinDepartment of Diabetes, Endocrinology and Metabolism, Galilee Medical Center and Azrieli Faculty of Medicine, Bar-Ilan University of Safed, Nahariyya, Israel.
Hefziba GreenDepartment of Internal Medicine A, Kaplan Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Haitham Abu KhadijaDepartment of Cardiology, Kaplan Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Shay TeitlboimPharmacy Services, Kaplan Medical Center Faculty of Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Meital Zikry DeitchIntensive care unit, Kaplan Medical Center, and Faculty of Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Mohammad AlneesDepartment of Cardiology, Kaplan Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Merav GreensteinMerav Statistical Consulting, Kaplan Medical Center, Rehovot, Israel.
Tal SchillerInstitute of Endocrinology, Diabetes and Metabolic Disease, Wolfson Medical Center, Holon, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Ethiopian ethnicity is linked to a higher risk of diabetes, yet data on disease characteristics and complications in Ethiopians with type 1 diabetes (T1D) are limited. This study aimed to assess clinical features and complication rates in Ethiopian versus non-Ethiopian T1D patients. Methods: This population-based retrospective cohort study included all patients insured in Clalit Health Services (CHS) who were considered to have T1D according to study criteria between January 1, 2000, and December 31, 2022. Patients were followed until December 31, 2023, for the development of composites of microvascular and macrovascular complications. Results: Among 12,759 T1D patients, 672 (5.3%) were Ethiopian, and 4,375 (34%) were diagnosed before age 18. The mean age was 30.4 years, 54% were male, and the mean BMI was 25.4 kg/m². Average follow-up was 10.9 years. In multivariable Cox regression models, Ethiopian ethnicity was an independent risk factor for microvascular complications (hazard ratio [HR] 1.325; 95% CI 1.124-1.563; p = 0.001) but was associated with a lower risk of macrovascular complications (HR 0.606; 95% CI 0.425-0.863; p < 0.001). Conclusions: The striking differences in diabetes-associated complications underscore the need for ethnic-specific and population-specific follow-up, therapeutic, and preventive approaches for T1D patients.

Indexed as

Diabetes ComplicationsDiabetes Mellitus, Type 1AdolescentAdultEthiopiaFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesRisk FactorsYoung Adultdiabetes mellitusEthiopian ethnicitymacrovascular complications of diabetesmicrovascular complications of diabetestype 1 diabetes (T1D)

Identifiers

PMID41180175
PMCPMC12575150

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