ArticleJournal of intensive medicine2025
Dynamic alterations of lymphocyte subsets following sepsis in octogenarian and elder patients.
Article in Journal of intensive medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Validation of SOFA-2 score in sepsis and exploration of its extension with additional immune markers.Journal of intensive medicine · 2026Article
- First-week absolute lymphocyte count dynamics and 28-day mortality in older adults with sepsis.BMC infectious diseases · 2026Article
- Failure of early lymphocyte recovery identifies sepsis patients with initial lymphopenia at highest risk for late mortality.PloS one · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sepsis is defined as a life-threatening organ dysfunction caused by dysregulated host responses to infections. This study aimed to investigate the early and dynamic changes in peripheral lymphocyte subsets following sepsis in octogenarian and elder patients and whether these changes were related to 28-day mortality. Methods: A prospective cohort study of 3601 consecutive patients admitted to the intensive care unit (ICU) was performed between March 2017 and January 2023. Peripheral blood samples were collected on admission, Day 3, and Day 7 for patients with sepsis and on enrollment for patients without sepsis. Lymphocyte subsets were detected by flow cytometry. The 28-day mortality was determined using Kaplan-Meier analysis, while Cox regression identified prognostic factors. Results: All enrolled patients were divided into three groups: adult (18-64 years), elder (65-79 years), and octogenarian (≥80 years). Sepsis induced a numerical reduction in lymphocytes (median=0.653 [IQR: 0.500-1.038] Conclusions: Sepsis induced a numerical reduction in lymphocytes and CD3
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