ArticleSAGE open medical case reports2025
Fever and rhabdomyolysis in a recent traveler: A case report of an uncommon presentation of anti-synthetase syndrome.
Article in SAGE open medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Anti-synthetase syndrome is a rare systemic autoimmune disease characterized by aminoacyl-tRNA synthetase autoantibodies. As an overlap disease, it can present heterogeneously with Raynaud's phenomenon, rash, arthritis, interstitial lung disease, or myositis. Rhabdomyolysis is not commonly seen. Diagnosis of anti-synthetase syndrome is based on autoantibody positivity and clinical presentation and may be supported by muscle biopsy. We describe an unusual case of a 28-year-old woman with anti-Jo-1 anti-synthetase syndrome presenting with isolated rhabdomyolysis without lung or skin involvement. Our case also describes concurrent influenza infection as a potential trigger for anti-synthetase syndrome. This case illustrates the variability and potential severity of this rare syndrome.
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