ArticleOpen forum infectious diseases2025
Persistent Subclinical Inflammation and Long-term Functional and Cognitive Outcomes After Dengue Shock and Septic Shock in Vietnam.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Mechanistic constraints in dengue severity: a systematic review with evidence stratification and agent-based evaluation of logical sufficiency.Frontiers in immunology · 2026Pooled it
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There have been no studies reporting functional, cognitive, inflammatory or endothelial outcomes after dengue shock (DS), or septic shock (SS) in Vietnam. Methods: We conducted a prospective observational study to follow-up adult survivors of DS and SS. At hospital discharge, 1-, 3-, and 6-month follow-up, we measured health-related quality of life (EQ-5D-5L), cognitive function (Montreal Cognitive Assessment, MoCA), endothelial function (EndoPAT), and plasma biomarkers of inflammation (ferritin, IL-6, CRP) and endothelial activation (Ang1, Ang2, VCAM-1). Results: Participants included survivors of DS (n = 130), SS (n = 26), and healthy controls (n = 25). Survivors of DS had median EQ-5D-5L visual analogue score (VAS) > 90/100 at all time-points, and mildly impaired MoCA scores at hospital discharge, which had normalized by 3 months (normal ≥ 26, median [25th;75th centile] 23/30 [20;26] at discharge, 27/30 [25;29] by 3 months). Survivors of SS had lower median EQ-5D-5L VAS at all time-points (median [25th;75th centile] 80/100 [70;95] at discharge, and 90/100 [80;95] by 6 months), but MoCA scores never returned above the normal threshold (median 17/30 [13;19] at discharge, 20/30 [17;21] at 6 months). We found higher IL-6 and ferritin at all post-discharge time points in both DS and SS groups versus healthy controls ( Conclusions: This is the first report of persistent subclinical inflammation after DS, and SS in Vietnam; further research is required to determine the duration and clinical significance of this phenomenon.
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