ArticleEuropean heart journal open2025
Markers of sudden cardiac death associated with the ventricular-paced 12-lead ECG.
Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: ECG markers are associated with increased risk of sudden cardiac arrest (SCA) on the sinus rhythm ECG. A sizeable subgroup of patients at risk receives cardiac implantable electrical devices, but there are no known markers of SCA risk on the ventricular-paced (VP) ECG. Methods and results: We conducted a case-control analysis within a community-based SCA study in Oregon USA (2002-2020; ∼1 million catchment population) with validation in an identically designed study in California USA (2015-2023; ∼850 000 catchment population). SCA cases included adults (≥18 years) with archived VP ECGs obtained prior and unrelated to their SCA. Controls met the same ECG criteria but without history of ventricular arrhythmias or SCA. The discovery analysis included 158 participants (119 SCA, 39 controls), mean age 76.9 ± 11.8 years. SCA cases had a higher ventricular rate (74.9 ± 16.0 bpm vs. 69.3 ± 12.0 bpm, Conclusion: Abnormal myocardial repolarization measured by QTc and Tpe was independently associated with SCA. These findings suggest that the VP ECG could also predict SCA risk.
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