ArticleFrontiers in medicine2025
Case Report: Coexisting cold agglutinin disease and acquired hemophilia A: a rituximab-responsive dual autoimmune disorder.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This report describes the first documented case of concurrent cold agglutinin disease (CAD) and acquired hemophilia A (AHA) in a 53-year-old male presenting with recurrent hematuria, hematemesis, and cold-induced acrocyanosis. Diagnostic findings included severe anemia with hemoglobin of 61 g/L, markedly prolonged activated partial thromboplastin time (aPTT, 88.6 s), critically reduced factor VIII activity (1.4%), a factor VIII inhibitor titer of 3.6 Bethesda units, and an elevated cold agglutinin titer of 1:320. Initial immunosuppression with corticosteroids and cyclophosphamide failed to improve either the coagulopathy or hemolytic anemia, consistent with the recognized poor response of CAD to steroid therapy. Clinical deterioration occurred during steroid tapering, complicated by hospital-acquired pneumonia. Administration of rituximab (375 mg/m
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