Evidence map›Paper›PMID 41179775›Full record

ArticleFrontiers in public health2025

Time to first dose of measles-containing vaccine and associated factors among infants in Ethiopia: a survival analysis from performance monitoring for action data.

Eyob Tilahun Abeje, Ermias Bekele Enyew, Chala Daba, Lakew Asmare, Fekade Demeke Bayou, Mastewal Arefaynie, Anissa Mohammed, Abiyu Abadi Tareke, Awoke Keleb, Natnael Kebede and 4 more

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Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eyob Tilahun AbejeDepartment of Epidemiology and Biostatistics, School of Public Health, College of Health Sciences, Wollo University, Dessie, Ethiopia.
Ermias Bekele EnyewDepartment of Health Informatics, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Chala DabaDepartment of Environmental Health College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Lakew AsmareDepartment of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.
Fekade Demeke BayouDepartment of Epidemiology and Biostatistics, School of Public Health, College of Health Sciences, Wollo University, Dessie, Ethiopia.
Mastewal ArefaynieDepartment of Reproductive and Family Health, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Anissa MohammedDepartment of Epidemiology and Biostatistics, School of Public Health, College of Health Sciences, Wollo University, Dessie, Ethiopia.
Abiyu Abadi TarekeNossal Institute for Global Health, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia.
Awoke KelebDepartment of Environmental Health College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Natnael KebedeDepartment of Health Promotion, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Yawkal TsegaDepartment of Health System and Management, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Abel EndawkieDepartment of Epidemiology and Biostatistics, School of Public Health, College of Health Sciences, Wollo University, Dessie, Ethiopia.
Shimels Derso KebedeDepartment of Health Informatics, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Kaleab Mesfin AberaDepartment of Health System and Management, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The measles-containing vaccine (MCV) is a live attenuated vaccine that helps to develop lifelong immunity, and it prevents measles outbreak when administered at the right time in measles-endemic areas. Many infants received the initial dose of the measles vaccine later than the ideal time frame, and significant others missed the vaccination, causing a recurrent measles outbreak in Ethiopia. This study assessed the time to the first dose of a measles-containing vaccine and associated factors among infants in Ethiopia. Methods: A cohort of 1,770 mother-infant pairs was analysed using data from the performance monitoring for action Ethiopia dataset. Cohort-2 Ethiopian data set was collected in Addis Ababa, Amhara, Oromia and SNNP regions between between November 2021 and August 2023. The key independent variables were socio-demographic characteristics, maternal health service utilization, and pregnancy intention. Multiple imputation was used to handle missing data. Survival analysis was conducted using R programming language version 4.4.1. Multicollinearity was assessed using Generalized variance inflation factors (GVIF), and model fit was evaluated using concordance index and overall model significance. Results: Among 1,770 infants followed, only 27% were vaccinated timely, within 9-10 months of age (survival probability = 0.73), and 53.4% had not yet received MCV1 at 12 months of age. The hazard of receiving the first dose of measles vaccine (MCV1) was 35% lower among infants from pregnancies that were not desired at all (AHR = 0.65, 95% CI: 0.46-0.93) and 21% lower among those infants from pregnancies that were initially undesired but later became wanted (AHR = 0.79, 95% CI: 0.65-0.96), compared to infants from pregnancies that were desired from the beginning. Conclusion: Despite progress in the uptake of the first dose of measles vaccine, timely vaccination in Ethiopia is still low, and many infants in Ethiopia miss the immunization. Institutional delivery, maternal intention regarding pregnancy, religion, and wealth quantile were key predictors of the timeliness of the first dose of measles vaccine. Interventions encouraging institutional deliveries, supporting unintended pregnancy, working with religious leaders, and conducting continuous outreach to immunization services are necessary to improve the timely uptake of the first dose of measles vaccine.

Indexed as

Immunization ScheduleMeaslesMeasles VaccineVaccinationAdultCohort StudiesEthiopiaFemaleHumansInfantMaleSurvival AnalysisTime FactorsMeasles Vaccinechild healthMCV1measles-containing vaccinemeasles immunizationsurvey design survival analysistimeliness of measles first dose

Identifiers

PMID41179775
PMCPMC12571857

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.