ArticleARYA atherosclerosis2025
Serum levels of C1q/TNF-related protein-1 (CTRP1) and CTRP3 in patients with coronary artery disease.
Article in ARYA atherosclerosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundResearch suggests that C1q/TNF-related proteins (CTRPs) play a role in inflammation and may impact coronary artery disease (CAD). This study aimed to measure their levels in CAD patients and assess their correlation with disease severity.
methodsThis study involved 88 individuals (50 men and 38 women) who underwent coronary angiography. Among them, 47 patients had significant coronary obstruction and were selected as the case group, and 41 individuals without significant obstruction were considered as the control group. Serum levels of CTRP1 and CTRP3 were quantified using the ELISA method, whereas other parameters were assessed by standard laboratory techniques. Multiple logistic regression analysis was used to examine the association between CTRP1 and CTRP3 levels with CAD.
resultsThe mean age of CAD patients was 62.1 ± 11.5 years. Thirty-one patients were male and sixteen were female. The control group comprised nineteen men and twenty-two women, with a mean age of 62.3 ± 12.7 years. The concentrations of CTRP1 and CTRP3 proteins were significantly higher in individuals with CAD relative to controls. Except for serum HDL levels, which were lower in the CAD group than in the control group, there were no significant differences in the demographic or clinical features between the studied groups. A direct and significant association was discovered between the amounts of assessed adipokines and the severity of CAD.
conclusionA greater concentration of both CTRP1 and CTRP3 was strongly associated with the presence and severity of CAD, indicating that these adipocytokines may serve as markers for CAD.
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