ArticleArchives of Razi Institute2025
The severity of COVID-19 infection correlation with IL-17 polymorphism.
Article in Archives of Razi Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Single nucleotide polymorphisms (SNPs) in many studied genes have been related to the severity of COVID-19. This study was carried out to investigate whether the polymorphisms of two SNPs (rs763780 and rs2275913) of the gene polymorphisms for Interleukin 17 (IL-17) are connected to the COVID-19 severity. The effect of these polymorphisms on the levels of IL-17 and the relationship between the level of IL-17 and the severity of COVID-19 were also investigated. The real-time polymerase chain reaction (RT-PCR) was performed to detect SARS-COV-2. Blood samples were obtained for the analyses of IL-17 levels by enzyme-linked immunosorbent assay, and Genomic DNA was extracted for genotyping. It should be noted that genotyping was performed using RT-PCR. The results indicated that the IL-17 level significantly increased in the case group, compared to the control group (healthy people), and there was a relationship between the severity of COVID-19 and IL-17 levels (
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