ArticleArchives of Razi Institute2025
Rabbit Corneal Wound Treatment Using Small Intestinal Submucosa (SIS) and Platelet Rich Plasma (PRP) Scaffold.
Article in Archives of Razi Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic corneal wounds elicit a multitude of inflammatory reactions. This severe inflammation can lead to fibrosis or scarring on the cornea's surface by inhibiting the growth of the natural epithelium. The present study investigates the healing effects of two simultaneous treatments of small intestine submucosal graft (SIS) and platelet-rich plasma (PRP) in rabbit corneal wound healing. Twenty white New Zealand rabbits, with an average weight of 2.5 to 3 kilograms, exhibiting no clinical signs of ocular disease, were selected for the study. These rabbits were divided into four groups, with a total of five animals per group, for the purpose of a wound induction test using a crescent knife. Subsequent to wound formation, the groups under study included a control group (absence of corneal wound covering with only physiological serum), PRP+SIS, SIS, and PRP in the form of 1 cc subconjunctival drops of PRP every 12 hours. In groups with SIS, the dressing was placed on the wound with a circumferential suture. A clinical eye examination and fluorescein staining were performed to assess the wounds in terms of size, infection, turbidity, and edema. Twenty-one days after the operation, half of the animals from each group were euthanized, and their corneas were evaluated by histopathology. On the 21st day of the study, the PRP+SIS group exhibited the lowest level of corneal opacity. In the histopathological evaluation, the calculation of the number of rows of epithelium was not significant. The corneas of the PRP and SIS + PRP groups, as well as the SIS group, exhibited significantly less vascularization compared to the control group. The order of stromal collagens proved to be a significant factor in both the SIS group with SIS + PRP and the control group with SIS + PRP. A statistically significant difference in the extent of edema was observed between the control group and the SIS + PRP and PRP groups. A statistically significant decrease in inflammation was observed between the control and SIS+PRP groups, with the latter exhibiting markedly reduced levels of inflammation. The findings of this study demonstrate that the simultaneous use of SIS and PRP is not feasible.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.