ArticleClinical case reports2025
Case Report: Carcinoma Ex-Pleomorphic Adenoma With Concurrent Submandibular Gland Lithiasis-A Rare Association With Potential Pathophysiological Implications.
Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A case report of pleomorphic adenoma in a 27-year-old female.Radiology case reports · 2026Article
- Case Report: Carcinoma Ex-Pleomorphic Adenoma With Concurrent Submandibular Gland Lithiasis-A Rare Association With Potential Pathophysiological Implications.Clinical case reports · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
This case report details the exceptionally rare co-occurrence of submandibular gland lithiasis and carcinoma ex-pleomorphic adenoma (CXPA), representing only the fourth documented instance worldwide. The patient, a 79-year-old male with a 10-year history of recurrent submandibular symptoms, was found to have both ductal and intraglandular stones alongside non-uniform glandular enlargement. Post-surgical analysis confirmed CXPA. The patient remained disease-free with good functional outcomes at 24-month follow-up. This case provides valuable insights, suggesting a potential pathophysiological link between the chronic inflammation associated with long-standing lithiasis and the malignant transformation leading to CXPA. It underscores the importance of comprehensive diagnostic evaluation for chronic or atypical submandibular gland conditions to rule out concurrent malignancy.
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