ArticleFrontiers in cardiovascular medicine2025
Relationship between recurrently elevated hsCRP and adverse cardiovascular events among depressed patients in China: a time-to-event analysis.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06239246 (Analyzing the Association Between Cardiovascular Diseases and Mental Illness Considering Environmental Risk Factors), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Analyzing the Association Between Cardiovascular Diseases and Mental Illness Considering Environmental Risk Factors
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5 authors.
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Abstract
Context: Persistent inflammation has been considered a biological link between depression and cardiovascular diseases(CVDs). Multipoint assessments of inflammation provide a more reasonable understanding of an individual's inflammatory status compared to single-point measurements. However, few studies have established strategies to investigate multipoint measurements of plasma high-sensitivity C-reactive protein(hsCRP). Aims/Objective/Hypothesis: To elucidate the association between recurrent elevations in hsCRP and cardiovascular events among depressed patients. Methods: This retrospective cohort study analyzed medical records over a ten-year follow-up to evaluate the association between longitudinal hsCRP patterns and recurrent cardiovascular events in patients with depression. An age-adjusted gamma frailty time-to-event model was used to assess the risk for three primary outcomes: chronic ischemic heart disease (CIHD), atrial fibrillation (AF) and other arrhythmias, and major adverse cardiac events (MACE). The cumulative incidence of these recurrent events was estimated using the Mean Cumulative Function (MCF). Results: The study included 10,770 patients [7,428 (68.97%) females]. Patients were classified into five groups based on hsCRP levels: hsCRP < 3 mg/L ( Conclusions: The gamma frailty time-to-event model indicated a link between persistent inflammation and cardiac events. Recurrent hsCRP elevations were more strongly associated with cardiovascular events than those observed in cross-sectional analyses. Trial Registration: NCT06239246; ChiCTR2400089334.
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