SynthesisFrontiers in cardiovascular medicine2025
Effects of high-intensity interval training on biomarkers and inflammatory factors in patients with heart failure: a meta-analysis of randomized controlled trials.
Synthesis in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Cardiac biomarkers in athletes and active individuals: a clinical review of exercise-induced elevations and diagnostic interpretation.Frontiers in physiology · 2026Review
- Does exercise modulate ferroptosis-related cardiovascular injury? Mechanistic evidence and translational boundaries.Frontiers in physiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Background: There is still controversy about the effect of high-intensity interval training (HIIT) on the levels of cardiac and inflammatory biomarkers in patients with heart failure compared with moderate-intensity continuous training (MCT) and conventional healthcare activities. This article is to systematically investigate the effects of HIIT on the levels of cardiac and inflammatory biomarkers in patients with heart failure compared with MCT and conventional healthcare activities. Methods: A computerized search of databases was conducted with the search year from the establishment of the database, and the screened results were subjected to quality assessment and data extraction, and the data was meta-analyzed using RevMan 5.4.1 software. Results: 11 randomized controlled trials (RCTs) were finally included (7 RCTs about BNP and NT-proBNP, 2 RCTs about inflammatory factors, and 2 RCTs involve both), containing a total of 904 study subjects, 457 in the observation group, and 447 in the control group. Meta-analysis showed that HIIT significantly reduced BNP and NT-proBNP levels in patients with heart failure compared with the control group (SMD = -1.33, 95% CI: -2.55∼-0.11, Conclusions: Compared with MCT and conventional healthcare activities, the implementation of HIIT in patients with heart failure can effectively reduce the levels of heart failure biomarkers and improve their health. However, the difference between HIIT and the control group was not significant in the regulation of inflammatory factors. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/#searchadvanced, PROSPERO CRD42024513099.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.