ReviewAfrican health sciences2025
Effects of Genetic polymorphism in susceptibility to schistosomiasis infection and adverse treatment outcomes.
Review in African health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Work in progress on infections, reproductive sexual health, education and non-communicable diseases.African health sciences · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schistosomiasis is a serious tropical disease that is undiagnosed (Neglected tropical disease -NTD). The only disease with a more detrimental socio-economic impact than its causative agent is malaria. Over 250 million individuals are presently afflicted with Schistosomiasis haematobium, and an additional 779 million people are at risk of infection in regions where the disease is endemic. Africa is home to many incidences, which account for roughly 90% of infections. Every year in underdeveloped nations, schistosomiasis claims the lives of 11,700 people and disables over 3.3 million others. The parasite is still dangerous everywhere in the world, even in non-endemic places. This review delves deeply into genetic polymorphism and its different forms. It also addresses genetic polymorphism to susceptibility. It has been found that environmental factors are among the many variables that influence susceptibility to schistosomiasis. Schistosomiasis susceptibility is influenced by age, gender, and even pathological infections. The primary locus SM1, situated on chromosome 5q31-q33, regulates the extent of S. mansoni and S. haematobium infection by including multiple genes associated with the Th2 immune response. The chromosome 5q31-q33 Th2 cluster gene, which regulates the synthesis of interleukin 13, interleukin 4, and interleukin 5, is primarily linked to an increased risk of developing schistosomiasis.
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