ArticleJSES reviews, reports, and techniques2025
Prevalence of amyloid deposition in distal biceps tendon ruptures: a retrospective review of intraoperative biopsy.
Article in JSES reviews, reports, and techniques, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Tissue Screening and Diagnosis of Transthyretin Amyloid Cardiomyopathy.Reviews in cardiovascular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In a previous study, one-third of patients with heart failure secondary to wild-type transthyretin amyloidosis were found to have distal biceps tendon (DBT) ruptures, and a large proportion of these ruptures were spontaneous or asymptomatic. This rate is higher than the 2.5% incidence of DBT ruptures seen in patients with other causes of heart failure. DBT ruptures can be used as a screening opportunity for early detection of systemic amyloidosis. However, when a subsequent study investigated the rate of amyloid deposition in 30 patients with acute DBT ruptures, only 3% had evidence of amyloid deposition. Although that study was powered to detect a DBT rupture prevalence of 33%, we suspect the real prevalence of amyloid deposition in patients presenting with DBT ruptures is lower, and a higher-powered study would help to better understand the role of intraoperative biopsy of DBT ruptures for systemic amyloidosis screening. Methods: This study is a retrospective review of 53 patients with DBT ruptures who underwent operative repair at a single institution between June 2022 and June 2024. At the time of surgery, a tissue sample was taken from the DBT and sent as a specimen for evaluation. Specimens were reviewed by board-certified pathologists under microscopy, and Congo red staining was performed to evaluate for amyloid deposition. Specimens that stained positive for amyloid were sent to an outside facility for liquid chromatography tandem mass spectrometry for confirmation and subtype identification. Patient demographic data were collected by a retrospective chart review. Results: Of the 53 included patients, 4 (9.43%) were positive for amyloid deposition on Congo red staining and liquid chromatography tandem mass spectrometry. No patients had a diagnosis of amyloidosis or cardiac manifestations of amyloidosis at the time of repair. Conclusion: Intraoperative biopsies of DBT ruptures may be a valuable tool for early detection of amyloid deposition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.