Evidence map›Paper›PMID 41179295›Full record

ArticleOncology research2025

RAD23B Promotes Colorectal Cancer Metastasis via the Talin1/Integrin/PI3K/AKT/MMP9 Axis.

Jun Li, Yang Chen, Zhijiao Hao, Zhiyong Zhang, Jingyi Fan, Xiao Liu, Xueli Zhao, Hongyan Zhang, Chenpeng Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun LiDepartment of Clinical Laboratory, Tangshan Gongren Hospital, Tangshan, 064300, China.
Yang ChenDepartment of Clinical Laboratory, Tangshan Gongren Hospital, Tangshan, 064300, China.
Zhijiao HaoClinical School of North China University of Science and Technology, Tangshan, 064300, China.
Zhiyong ZhangDepartment of Pathology, Tangshan Gongren Hospital, Tangshan, 064300, China.
Jingyi FanDepartment of Clinical Laboratory, Tangshan Gongren Hospital, Tangshan, 064300, China.
Xiao LiuDepartment of Clinical Laboratory, Tangshan Gongren Hospital, Tangshan, 064300, China.
Xueli ZhaoDepartment of Pathology, Tangshan Gongren Hospital, Tangshan, 064300, China.
Hongyan ZhangDepartment of Clinical Laboratory, Tangshan Rehabilitation Medical Center, Tangshan, 064300, China.
Chenpeng WuDepartment of Pathology, Tangshan Gongren Hospital, Tangshan, 064300, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Radiation sensitive 23 homolog B (RAD23B), a DNA repair-related protein, plays a contributory role in the development of multiple malignancies. This study aimed to explore the role of RAD23B in promoting colorectal cancer (CRC) metastasis and to elucidate the underlying molecular mechanisms. Methods: RAD23B was overexpressed in CRC cell lines SW480 and HCT-8, with empty vectors serving as controls. Invasion, cell proliferation, and migration were assessed using CCK-8 and Transwell assays. A xenograft mouse model was used to evaluate metastatic potential Results: RAD23B overexpression notably enhanced CRC migration, cell proliferation, and invasion both Conclusion: RAD23B facilitates CRC metastasis through activation of the Talin1/Integrin αv/β1/PI3K/AKT/MMP9 signaling axis. These results provide novel insights into the role of RAD23B in CRC progression and identify it as a potential therapeutic target.

Indexed as

Colorectal NeoplasmsDNA-Binding ProteinsDNA Repair EnzymesMatrix Metalloproteinase 9Proto-Oncogene Proteins c-aktTalinAnimalsCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansIntegrinsMaleMiceDNA-Binding ProteinsDNA Repair EnzymesIntegrinsMatrix Metalloproteinase 9MMP9 protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRAD23B protein, humanTalinTLN1 protein, humanColorectal cancermetastasisradiation sensitive 23 homolog B

Identifiers

PMID41179295
PMCPMC12573188

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.