Evidence map›Paper›PMID 41179289›Full record

ReviewOncology research2025

Exosomal Non-Coding RNAs in Pancreatic Cancer: From Mechanisms to Clinical Applications.

Chengru Yang, Zhiyu Wang, Shaowu Bi, Xinmiao Zhang, Zhaoqiang Xu, Yifei Ge, Tianjie Zhang, Nan Wang, Yi Xu, Xiangyu Zhong

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chengru YangDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang, 150086, China.
Zhiyu WangDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang, 150086, China.
Shaowu BiDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang, 150086, China.
Xinmiao ZhangDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang, 150086, China.
Zhaoqiang XuDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang, 150086, China.
Yifei GeDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang, 150086, China.
Tianjie ZhangDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang, 150086, China.
Nan WangDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang, 150086, China.
Yi XuDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang, 150086, China.
Xiangyu ZhongDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang, 150086, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer (PC) is an extremely aggressive cancer of the digestive system with insidious onset and the lack of effective biomarkers, resulting in late-stage diagnosis and poor prognosis. Exosomal non-coding RNAs (ncRNAs) are key mediators of intercellular communication that drive PC initiation and advancement. By modulating gene expression, they impact tumor microenvironment (TME) remodeling, proliferation, migration, apoptosis, and immune evasion. Critically, exosomal ncRNAs serve as promising biomarkers for early diagnosis and prognostic assessment. This review summarizes the current research achievements regarding exosomal ncRNAs in PC, systematically elaborating on their roles in tumor occurrence, metastasis, chemoresistance and the TME. Furthermore, by integrating the potential of exosomal ncRNAs in the diagnosis, treatment and prognosis of PC and by highlighting the challenges and future directions, this review aims to offer novel insights for future research and clinical translation of exosomal ncRNAs in PC.

Indexed as

Antineoplastic AgentsBiomarkers, TumorExosomesPancreatic NeoplasmsRNA, UntranslatedAnimalsCell-Free Nucleic AcidsCell MovementCell ProliferationDisease-Free SurvivalEarly Detection of CancerEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansLiquid BiopsyNeoplasm InvasivenessAntineoplastic AgentsBiomarkers, TumorCell-Free Nucleic AcidsRNA, UntranslatedbiomarkerdiagnosisExosomesnon-coding RNAspancreatic cancertherapy

Identifiers

PMID41179289
PMCPMC12573195

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.