ArticleJCEM case reports2025
Therapeutic Plasma Exchange in Severe Graves Disease With Hematologic and Hepatic Complications.
Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Therapeutic Plasma Exchange for Complicated Hyperthyroidism: A Case Series.Journal of clinical apheresis · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report 2 young women with severe Graves thyrotoxicosis in whom antithyroid drugs were contraindicated-one due to drug induced moderate neutropenia and the other due to Graves disease-associated hepatic dysfunction and cytopenia. Both patients presented with life-threatening manifestations of thyrotoxicosis and were unsuitable for immediate surgery or radioiodine therapy. Therapeutic plasma exchange (TPE) was used as a bridging strategy to achieve rapid biochemical control. In the first case, a single session of TPE enabled prompt stabilization for total thyroidectomy. In the second, 3 sessions of TPE led to marked clinical improvement, reversal of hepatic dysfunction and cytopenia, and facilitated successful radioiodine ablation. Neither patient experienced TPE-related complications. These 2 cases highlight the utility of TPE as a safe and effective interim therapy in complicated thyrotoxicosis, allowing timely transition to definitive treatment in high-risk clinical settings where conventional antithyroid therapies are contraindicated.
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Registered trials
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