Evidence map›Paper›PMID 41179187›Full record

ArticleACS omega2025

Submerged Fermentation of

Nicoly Subtil de Oliveira, Romeu Cassiano Pucci da Silva Ramos, Pedro Andrade de Souza, Vinicius Chaves Mesacasa, Luiz Fernando Bianchini, Edvaldo Antonio Ribeiro Rosa

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicoly Subtil de OliveiraXenobiotics Research Unit, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Brazil.ORCID https://orcid.org/0000-0002-5570-8036
Romeu Cassiano Pucci da Silva RamosXenobiotics Research Unit, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Brazil.
Pedro Andrade de SouzaXenobiotics Research Unit, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Brazil.ORCID https://orcid.org/0009-0008-7986-8588
Vinicius Chaves MesacasaXenobiotics Research Unit, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Brazil.
Luiz Fernando BianchiniXenobiotics Research Unit, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Brazil.
Edvaldo Antonio Ribeiro RosaXenobiotics Research Unit, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Brazil.ORCID https://orcid.org/0000-0001-6087-4365

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

l-asparaginase (L-ASNase) has garnered considerable interest in lymphoma therapy due to its mechanism of action, which involves depleting the availability of circulating l-asparagine, a crucial nutrient for malignant cells. Given the notable side effects of commercially available bacterial L-ASNase and the existing challenges in large-scale industrial production, this study focused on identifying and optimizing novel fungal sources for the enzyme. The research methodology involved initial strain screening, development and optimization of a bioreactor system, and subsequent evaluation of enzyme production within a bioprocess. A comprehensive screening of various fungal strains revealed that

Identifiers

PMID41179187
PMCPMC12573016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.