ArticleACS omega2025
Nanophotosensitizers Based on Celecoxib-Conjugated Chitosan Using a Thioketal Linkage for the Reactive Oxygen Species-Mediated Delivery of Chlorin E6 and Treatment of Oral Cancer Cells.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
A celecoxib (CELE)-grafted chitosan copolymer was synthesized using a thioketal linkage for oxidative stress-mediated delivery of chlorin e6 (Ce6) and enhanced photodynamic therapy (PDT) against oral squamous carcinoma. CELE was conjugated to the amine groups of chitosan using thioketal dicarboxylic acid as a linker, resulting in the synthesis of a CELE-grafted chitosan (ChitoCELE) copolymer. The ChitoCELE copolymer was reconstituted in water, and Ce6 was subsequently incorporated to produce Ce6-incorporated ChitoCELE nanophotosensitizers. These nanophotosensitizers exhibited a spherical morphology with a diameter of less than 200 nm. Disintegration of the nanophotosensitizers was observed upon exposure to hydrogen peroxide, leading to an increased drug release rate. These results indicated that the nanophotosensitizers are sensitive to oxidative stress
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