Evidence map›Paper›PMID 41179117›Full record

ArticleTherapeutic advances in medical oncology2025

Effects of radiotherapy in borderline and malignant phyllodes tumors after R0 resection: a propensity score analysis.

Bingbing Ma, Xiaojun Li, Zilin Zhuang, Mengjia Han, Yulu Zhang, Feng Ye, Zhuofei Bi, Wen Deng, Jiahao Zhang, Yaping Yang and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in medical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07657169 (Efficacy and Safety of Molecular Subtype-Guided Postoperative Radiotherapy for Phyllodes Tumor of the Breast), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07657169 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy and Safety of Molecular Subtype-Guided Postoperative Radiotherapy for Phyllodes Tumor of the Breast: A Prospective, Open-Label, Randomized Controlled Trial

TypeinterventionalSponsorSun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityRan2026 to 2030Enrolled160ConditionsRadiotherapy, Adjuvant, Phyllodes Breast Tumor, Prognosis, Molecular TypingArmsPostoperative Radiotherapy (PORT)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bingbing MaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Xiaojun LiGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Zilin ZhuangGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Mengjia HanGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Yulu ZhangDepartment of Breast Surgery, Nanchang Third Hospital, Nanchang, Jiangxi, China.
Feng YeDepartment of Breast Oncology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0001-9029-1574
Zhuofei BiDepartment of Radiation Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Wen DengCenter for Biotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Jiahao ZhangDepartment of Clinical Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
Yaping YangGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 Yanjiang West Road, Guangzhou 510120, China.
Yan NieGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 Yanjiang West Road, Guangzhou 510120, China.ORCID https://orcid.org/0000-0002-8111-6050

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Breast phyllodes tumors (PT) are rare fibroepithelial tumors classified by the World Health Organization into benign, borderline, and malignant subtypes. Although surgery is the primary treatment, local recurrence remains a concern. The role of postoperative radiotherapy (PORT) in improving local control remains unclear. Objectives: This study aimed to investigate the effect of PORT in patients with borderline PT (BoPT) and malignant PT (MPT) after R0 resection (complete resection without tumor margins) and to identify prognostic factors related to local recurrence-free survival (LRFS) and overall survival (OS). Design: This was a retrospective multicenter study. Methods: We retrospectively evaluated patients with BoPT and MPT who underwent R0 resection between January 2002 and October 2023. Propensity score matching was used to balance the covariates between the PORT ( Results: Of 480 patients, 438 (91.25%) underwent surgery alone and 42 (8.75%) received PORT. PORT did not improve the LRFS or OS. After matching, 5-year LRFS (71.42% vs 70.17%, Conclusion: In our study, PORT did not significantly improve LRFS or OS in patients with BoPT and MPT. Key prognostic factors may guide treatment decisions in these patients.

Indexed as

phyllodes tumorspropensity score matchingradiotherapyrecurrence

Identifiers

PMID41179117
PMCPMC12575932

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.