ArticleCureus2025
Comparing Osteoarthritis Burden Across Central, Eastern, and Western Europe (1990-2021): Insights From the Global Burden of Disease Study 2021.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aim Osteoarthritis ranks as one of the leading causes of disability, predominantly affecting adults aged 70 years and older. This study aimed to report trends in the burden of osteoarthritis from 1990 to 2021 based on the Global Burden of Diseases Study (GBD) 2021 across Central, Eastern, and Western Europe. Methods This study is a systematic analysis of secondary database estimates from the GBD 2021 study for osteoarthritis in Central, Eastern, and Western Europe, as well as the 44 countries. The age-standardized rates of incidence, prevalence, and years of life lost due to disability were evaluated by age, gender, and high body mass index (BMI). Results In 2021, there were 101.2 million (95% uncertainty interval {UI}, 90.4-112.6 million) prevalent cases of osteoarthritis, a 48.3% increase from 1990. Subregional estimates showed that the incidence, prevalence, and years lived with disability (YLDs) cases in Western Europe were more than twice the number in Eastern Europe and more than four times the number in Central Europe, and had higher disability rates in young adults than their two other counterparts. Osteoarthritis accounted for approximately 6.7 million (95% UI 4.1-5.2 million) incidents, and there were 3.6 million YLDs (95% UI, 1.7-7.3) in Europe across all age groups. There was a positive association between the rising BMI in individuals under 50 years of age and the age-standardized rates of YLDs. Conclusion Between 1990 and 2021, the prevalence of osteoarthritis across Europe has consistently increased across all age groups, exerting considerable pressure on the workforce as it increasingly affects individuals under 50 years of age. To help reduce this impact, the World Health Organization advocates recognizing high BMI as an independent disease, an approach that would directly address a key contributor to the heightened disability and health complications linked to osteoarthritis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.