ArticleCureus2025
Anthocephalus indicus and Terminalia arjuna Combination Ameliorates Hematological and Histopathological Changes in a Rat Model of Metabolic Syndrome.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Biological Activities, Medicinal Uses, and Nutritional Effects ofFood science & nutrition · 2026Review
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6 authors.
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Abstract
backgroundMetabolic syndrome and diabetes mellitus are among the most common chronic disorders worldwide, posing significant challenges to healthcare systems. They are characterized by persistent high blood glucose levels, insulin resistance, and progressive impairment of organs such as the pancreas, liver, kidneys, and heart. In the present study, we can evaluate the protective effects of a combined ethanolic extract of
methodsMale Wistar rats were divided into seven groups (n = 6): normal control, diabetic control (high-fat, high-fructose (HFHF) diet + streptozotocin (STZ)), individual extract-treated, combination-treated, metformin, and atorvastatin-treated. For 16 weeks, all groups (except the normal group) received a high-fat, high-fructose diet, followed by a low-dose streptozotocin (30 mg/kg body weight) injection to induce metabolic syndrome. The treatment phase included administration of individual extracts (500 mg/kg), combination extract (250 + 250 mg/kg), metformin (100 mg/kg), or atorvastatin (20 mg/kg). After the experimental period, animals were sacrificed, and organs, including the pancreas, kidney, liver, heart, lungs, and spleen, were examined histologically using hematoxylin and eosin staining.
resultsThe diabetic control group showed significant histopathological damage across all organs, including islet distortion, glomerular hypertrophy, hepatic ballooning, myocardial degeneration, alveolar disruption, and splenic architectural loss. Treatment with individual extracts showed partial protection. However, the combination-treated group exhibited marked histological restoration comparable to metformin, indicating synergistic organ-protective effects. Atorvastatin showed moderate structural recovery in most tissues. Hematological analysis further revealed anemia, leukocytosis, and thrombocytosis in the diabetic control group, while the combination extract significantly improved hemoglobin, red blood cell (RBC), hematocrit (HCT), and normalized leukocyte and platelet counts, effects comparable to metformin.
conclusionThe combined herbal formulation of
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