Evidence map›Paper›PMID 41179069›Full record

ReviewCureus2025

PD1/PD-L1 Axis Blockers in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis of Efficacy and Safety Outcomes.

Tarang Patel, Sagar Dholariya, Siddhartha Dutta, Gyanendra Singh, Krupal Joshi, Ashwini Agarwal, Sanjay Gupta, Deepa Shukla

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tarang PatelPathology, All India Institute of Medical Sciences, Rajkot, Rajkot, IND.
Sagar DholariyaBiochemistry, All India Institute of Medical Sciences, Rajkot, Rajkot, IND.
Siddhartha DuttaPharmacology, All India Institute of Medical Sciences, Rajkot, Rajkot, IND.
Gyanendra SinghPathology, All India Institute of Medical Sciences, Rajkot, Rajkot, IND.
Krupal JoshiCommunity and Family Medicine, All India Institute of Medical Sciences, Rajkot, Rajkot, IND.
Ashwini AgarwalMicrobiology, All India Institute of Medical Sciences, Rajkot, Rajkot, IND.
Sanjay GuptaForensic Medicine and Toxicology, All India Institute of Medical Sciences, Rajkot, Rajkot, IND.
Deepa ShuklaYoga (AYUSH), All India Institute of Medical Sciences, Jodhpur, Jodhpur, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancers of the head and neck are common, and this review aimed to systematically analyze the safety and efficacy of anti-PD1/PD-L1 inhibitors (API) therapies in head and neck squamous cell carcinoma (HNSCC). This is a systematic review of randomized controlled trials (RCTs) showcasing the safety and efficacy of APIs in HNSCC. An online literature search of PubMed, Cochrane database, and ClinicalTrials.gov was conducted till May 31, 2024, to identify RCTs involving anti-PD1/PD-L1 therapies in oral cancer. The data were analyzed using Review Manager (RevMan) (Cochrane, London, United Kingdom), and the risk of bias was assessed for methodological quality. This study included nine RCTs with 3933 study participants. API treatment showed a significant improvement in overall survival (OS) compared to standard therapy in HNSCC (hazard ratio (HR) =0.85 (0.76,0.95), I

Indexed as

anti-pd1/pd-l1 inhibitorshead and neck squamous cell carcinoma (hnscc)meta-analysispd-l1 expressionsystemic review

Identifiers

PMID41179069
PMCPMC12574755

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.