ArticleCureus2025
Post-COVID Neurodegeneration: A Puerto Rican Case of Rapidly Fatal Creutzfeldt-Jakob Disease.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
COVID-19 is a disease caused by the SARS-CoV-2 virus, and infection typically leads to the development of respiratory symptoms and illness. Neurodegenerative disorders following infection with SARS-CoV-2 have been reported. We report the case of a previously healthy 58-year-old native Puerto Rican man with a history of COVID-19 vaccination who developed Creutzfeldt-Jakob Disease (CJD) 14 days after a COVID-19 illness. The clinical features and disease course aligned with those described in post-COVID-19 CJD cases documented in the literature. Magnetic resonance imaging (MRI) revealed prominent T2/fluid attenuated inversion recovery (FLAIR) signal abnormalities within the entire cortex of both cerebral hemispheres. Cerebrospinal fluid (CSF) analysis revealed elevated 14-3-3 gamma concentrations, along with a positive real-time quaking-induced conversion (RT-QuIC), confirming the diagnosisofCJD. While further investigation is required to elucidate the relationship between these two pathologies, our study underscores the importance of close monitoring post COVID-19, as cognitive sequelae can be indicators of rapid neurodegenerative entities such as sporadic CJD (sCJD).
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