Evidence map›Paper›PMID 41179049›Full record

ArticleCureus2025

Anesthetic Considerations in Pediatric Corneal Neurotization: A Case Report.

José Enrique Díaz Vázquez, Mauricio Muleiro-Alvarez, Alejandra Botero-Benítez, María Alejandra Juárez Tirado, Javier Burgos Cárdenas, Neyra Xiomara Pérez Garcés, Tania Albavera-Giles, Alexandro Aguilera, Nicolás Kahuam-López, Arturo Ramirez-Miranda and 1 more

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

José Enrique Díaz VázquezAnesthesiology, Instituto de Oftalmología Fundación Conde de Valenciana es una Institución de Asistencia Privada, Mexico City, MEX.
Mauricio Muleiro-AlvarezCornea and Refractive Surgery, Instituto de Oftalmología Fundación Conde de Valenciana es una Institución de Asistencia Privada, Mexico City, MEX.
Alejandra Botero-BenítezCornea and Refractive Surgery, Instituto de Oftalmología Fundación Conde de Valenciana es una Institución de Asistencia Privada, Mexico City, MEX.
María Alejandra Juárez TiradoAnesthesiology, Instituto de Oftalmología Fundación Conde de Valenciana es una Institución de Asistencia Privada, Mexico City, MEX.
Javier Burgos CárdenasAnesthesiology, Instituto de Oftalmología Fundación Conde de Valenciana es una Institución de Asistencia Privada, Mexico City, MEX.
Neyra Xiomara Pérez GarcésAnesthesiology, Instituto de Oftalmología Fundación Conde de Valenciana es una Institución de Asistencia Privada, Mexico City, MEX.
Tania Albavera-GilesCornea and Refractive Surgery, Instituto de Oftalmología Fundación Conde de Valenciana es una Institución de Asistencia Privada, Mexico City, MEX.
Alexandro AguileraPlastic Surgery, Medpoint Plastic Surgery Clinic, Polanco, Mexico City, MEX.
Nicolás Kahuam-LópezCornea and Refractive Surgery, Instituto de Oftalmología Fundación Conde de Valenciana es una Institución de Asistencia Privada, Mexico City, MEX.
Arturo Ramirez-MirandaCornea and Refractive Surgery, Instituto de Oftalmología Fundación Conde de Valenciana es una Institución de Asistencia Privada, Mexico City, MEX.
Guillermo Raul Vera-DuarteCornea and Refractive Surgery, Instituto de Oftalmología Fundación Conde de Valenciana es una Institución de Asistencia Privada, Mexico City, MEX.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital corneal anesthesia (CCA) is a rare pediatric disorder characterized by absent or markedly reduced corneal sensation, predisposing to neurotrophic keratopathy and vision-threatening complications. Corneal neurotization has emerged as a surgical option to restore corneal innervation, but anesthetic considerations in pediatric cases remain scarcely reported. We present the anesthetic management of a six-year-old female child with CCA and recurrent herpetic keratitis following deep anterior lamellar keratoplasty, who underwent indirect corneal neurotization with a sural nerve graft. Anesthetic care focused on preoperative anxiety reduction, airway safety, multimodal analgesia, and limited neuromuscular blockade to facilitate intraoperative neuromonitoring. Standard monitoring included electrocardiography, non-invasive blood pressure, pulse oximetry, capnography, temperature, and ulnar nerve twitch assessment. Perioperative antiviral prophylaxis (oral acyclovir) was maintained, and ondansetron was administered for PONV prophylaxis. The four-hour procedure was uneventful, with stable hemodynamics and adequate postoperative pain control. Pain was assessed using the FLACC (Face, Legs, Activity, Cry, Consolability) scale, which remained at a level of <3/10 throughout the first 24 hours. This report highlights the importance of tailored anesthetic strategies in pediatric neurotization procedures, balancing surgical requirements with age-specific physiological considerations.

Indexed as

intraoperative managementmultimodal analgesianeurotizationpediatric anesthesiapostoperative carepreoperative anxiety reductionpreoperative care

Identifiers

PMID41179049
PMCPMC12574607

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.