ReviewCureus2025
Integrated Resuscitation Strategies in Orthopedic Trauma: A Systematic Review of Outcomes of Cardiopulmonary Resuscitation (CPR), Hemorrhage Control, and Damage Control.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthopedic trauma is a major cause of global morbidity and mortality, often resulting from high-energy mechanisms such as road traffic accidents, falls, and interpersonal violence. Early deaths are frequently due to hemorrhage, coagulopathy, and physiologic instability. This systematic review, following PRISMA 2020 guidelines, included six studies with a total of 28,549 patients. The majority came from the CRASH-2 randomized controlled trial (20,211 bleeding trauma patients, many with orthopedic injuries). The remaining five studies together contributed 8,338 patients to evaluate integrated resuscitation strategies: trauma-specific CPR, hemorrhage control (tourniquets, pelvic stabilization, massive transfusion protocols, tranexamic acid, resuscitative endovascular balloon occlusion of the aorta (REBOA)/embolization), and fracture fixation timing (damage control orthopedics vs early appropriate care/early total care). Evidence indicates that early hemorrhage control, physiologically guided resuscitation, and timely operative intervention improve survival, reduce complications, and optimize functional outcomes. Standardized, protocol-driven approaches and resource-sensitive adaptations remain essential for effective orthopedic trauma care.
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Registered trials
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