Evidence map›Paper›PMID 41178971›Full record

ArticleFrontiers in microbiology2025

Exploring the role of intestinal microbiota in mitigating acute radiation-induced intestinal injury through high-energy X-ray FLASH radiotherapy via metagenomic analysis.

Huan Du, Xiaofei Hao, Binwei Lin, Yihan Zhu, Yiwei Yang, Mingming Tang, Wei Wu, Decai Wang, Bo Lin, Yuwen Liang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Huan DuMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Xiaofei HaoMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Binwei LinMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Yihan ZhuMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Yiwei YangInstitute of Applied Electronics, China Academy of Engineering Physics, Mianyang, China.
Mingming TangClinical Medical School, North Sichuan Medical College, Nanchong, China.
Wei WuSchool of National Defense Science and Technology College SWUSST, Southwest University of Science and Technology, Mianyang, China.
Decai WangMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Bo LinMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Yuwen LiangClinical Medical School, North Sichuan Medical College, Nanchong, China.
Wenqiang TangClinical Medical School, North Sichuan Medical College, Nanchong, China.
Haonan XuClinical Medical School, North Sichuan Medical College, Nanchong, China.
Jie LiMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Feng GaoMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Xiaobo DuMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study preliminarily examines the potential correlation between the gut microbiome and the protective effects of FLASH radiotherapy (FLASH-RT) on intestinal tissue using metagenomic analysis. Methods: Compact single high-energy X-ray source (CHEXs) FLASH-RT was employed for FLASH irradiation, while EBT3 radiochromic film and a fast current transformer were used to measure the absolute dose and the pulsed beam characteristics. Sham radiotherapy (control), FLASH-RT (333 Gy/s), and Conventional dose rate radiotherapy (CONV-RT, 0.07 Gy/s) were performed on whole abdomen of normal C57BL/6J female mice (10 Gy, 12 Gy, 14 Gy). At 72 h post-irradiation, intestinal contents from normal C57BL/6J female mice were collected for metagenomic analysis. The survival status, body weight, and damage to normal tissues were observed. Results: At 28 days post-whole abdomen irradiation with doses of 12 Gy, the survival rate of the FLASH group was higher than that of the CONV group ( Conclusion: Compared to CONV-RT, high-energy X-ray FLASH irradiation exerts radioprotective effects on normal intestinal tissue. Alterations in the gut microbiota and associated signaling pathways may be linked to the protective effects of FLASH.

Indexed as

FLASH effectgut microbiomemechanismmetagenomicsX-ray FLASH

Identifiers

PMID41178971
PMCPMC12575193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.