Dietary inflammatory potential, genetic susceptibility, and systemic inflammation indices in relation to abdominal aortic aneurysm risk: a prospective cohort study.

Duoliang Wei, Yongliang Zhong, Xinyi Liu, Rutao Guo, Yipeng Ge, Zhiyu Qiao, Junming Zhu

Abstract read

In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Accelerated Biological Aging, Genetic Susceptibility, and the Risk of Abdominal Aortic Aneurysm: A Prospective Cohort Study.Reviews in cardiovascular medicine · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Duoliang Wei *Department of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.

Yongliang Zhong *Department of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.

Xinyi LiuDepartment of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.

Rutao GuoDepartment of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.

Yipeng GeDepartment of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.

Zhiyu QiaoDepartment of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.

Junming ZhuDepartment of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic inflammation and genetic susceptibility are important factors in abdominal aortic aneurysm (AAA) pathogenesis, yet evidence regarding the impact of dietary inflammation on AAA risk remains limited. This study aimed to investigate the association between dietary inflammatory potential, genetic susceptibility, and systemic inflammation in relation to AAA incidence. Methods: In this prospective cohort study, 142,862 participants from the UK Biobank were followed over an average of 13.8 years. Dietary inflammatory potential was assessed using the Energy-Adjusted Dietary Inflammatory Index (E-DII), while genetic susceptibility was quantified using polygenic risk scores (PRS) derived via PRS-CS methodology. Systemic inflammation indices, including the Systemic Immune-Inflammation Index and the Systemic Inflammation Response Index (SIRI), as well as nutritional and immunological status assessed by the Prognostic Nutritional Index and the Controlling Nutritional Status score, were also examined. In addition, the mediating roles of systemic inflammation indices were evaluated. Results: Higher E-DII scores were significantly associated with increased AAA risk (HR: 1.36, 95% CI: 1.09-1.71). Individuals with high PRS and high E-DII exhibited a markedly elevated AAA risk compared to those with low PRS and low E-DII (HR: 3.04, 95% CI: 2.21-4.79). SIRI mediated 9.16% (95% CI: 4.81%-17.90%) of the association between dietary inflammation and AAA. Conclusion: This study demonstrates that both dietary inflammatory potential and genetic susceptibility are associated with increased AAA risk, highlighting SIRI as a critical mediator. These findings suggest the potential utility of integrating dietary strategies, genetic screening, and inflammatory biomarkers into targeted AAA prevention programs.

Indexed as

abdominal aortic aneurysmcohort studydietary inflammationpolygenic risk scoresystemic inflammation response index

Identifiers

PMID41178951

DOI10.3389/fnut.2025.1680225

PMCPMC12576294

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.