Evidence map›Paper›PMID 41178948›Full record

ArticleFrontiers in nutrition2025

Study on the role of the combination of quercetin and lutein in alleviating ulcerative colitis in mice.

Zhiyue Xu, Si Mi, Bimal Chitrakar, Liwen Wang, Yingxi Li, Renli Shi, Yaxin Sang, Wenlong Yu, Xianghong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhiyue XuCollege of Food Science and Technology, Hebei Agricultural University, Baoding, China.
Si MiCollege of Food Science and Technology, Hebei Agricultural University, Baoding, China.
Bimal ChitrakarCollege of Food Science and Technology, Hebei Agricultural University, Baoding, China.
Liwen WangCollege of Food Science and Technology, Hebei Agricultural University, Baoding, China.
Yingxi LiCollege of Food Science and Technology, Hebei Agricultural University, Baoding, China.
Renli ShiCollege of Food Science and Technology, Hebei Agricultural University, Baoding, China.
Yaxin SangCollege of Food Science and Technology, Hebei Agricultural University, Baoding, China.
Wenlong YuCollege of Food Science and Technology, Hebei Agricultural University, Baoding, China.
Xianghong WangCollege of Food Science and Technology, Hebei Agricultural University, Baoding, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study aims to investigate the ameliorative effects and molecular mechanisms of combined quercetin and luteolin intervention on dextran sulfate sodium (DSS)-induced colitis in mice. Methods: By establishing a DSS-induced colitis model, we systematically evaluated the comprehensive effects of the combined treatment on colonic histopathological damage, inflammatory cytokine expression, intestinal barrier function, and gut microbiota composition. Results: The quercetin-luteolin combination treatment group significantly ameliorated colon shortening, with colon length restored to 7.33 ± 0.09 cm ( Discussion: Ultimately, a synergistic alleviation model characterized by "inhibition of inflammatory pathways-restoration of barrier function-regulation of microbial homeostasis" was established. This study provides a theoretical foundation for the application of quercetin and luteolin in the treatment of colitis.

Indexed as

colitisinflammatory factorintestinal microbiotaluteinquercetin

Identifiers

PMID41178948
PMCPMC12577482

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.