ArticleWorld journal of gastrointestinal surgery2025
Influencing factors and predictive model of the early postoperative recurrence of colorectal cancer with obstruction.
Article in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Emergency surgery for malignant large bowel obstruction: Assessing management options and outcomes.World journal of gastrointestinal surgery · 2026Article
- Natural Polymers Based Biocompatible Nanomedicines for Targeting Colon Cancer: Prospects and Challenges.International journal of nanomedicine · 2026Review
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5 authors.
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Abstract
backgroundIn cases of colorectal cancer (CRC) with obstruction, patients experience local tissue edema due to intestinal obstruction. This condition stimulates the accumulation of inflammatory factors, activates cancer cells, and increases the risk of tumor recurrence. At present, analyses and evaluation tools for factors influencing early postoperative recurrence in patients with CRC and obstruction are limited.
aimTo explore the influencing factors and construct a predictive model of the early postoperative recurrence of CRC with obstruction.
methodsData from 181 patients with CRC and obstruction who underwent surgery in the Department of Gastrointestinal Surgery, Suzhou Ninth Hospital Affiliated to Soochow University, between January 2017 and May 2023 were retrospectively collected. Patients with CRC and obstruction were divided into a recurrence group and a non-recurrence group based on whether recurrence occurred during the 2-year follow-up after surgery. Datasets from the two groups were compared. Subsequently, multiple logistic regression was employed to analyze the influencing factors of the early postoperative recurrence of CRC with obstruction. The nomogram prediction model was drawn using R software, and its performance was evaluated by the goodness of fit test and receiver operating characteristic (ROC) curve analysis. The clinical benefit rate of the model was evaluated by decision curves.
resultsAmong the 181 patients with CRC and obstruction, 52 (28.73%) experienced tumor recurrence within 2 years after surgery. Significant differences were observed in preoperative carcinoembryonic antigen (CEA), preoperative systemic immune-inflammation index (SII), tumor, node, and metastasis (TNM) stage, differentiation degree, nerve infiltration, and Ki-67 expression between the recurrence and non-recurrence groups (
conclusionThe early recurrence rate of CRC with obstruction is high. CEA, SII, TNM staging, differentiation degree, and Ki-67 expression are factors related to early postoperative recurrence. A nomogram prediction model incorporating these factors can effectively evaluate the risk of early postoperative recurrence in patients with CRC.
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