Evidence map›Paper›PMID 41178826›Full record

ArticleNeurodegenerative disease management2026

Guidelines addressing Motor Neurone Disease (MND): a scoping review.

Cindy Stern, Ines Semendric, Nipun Shrestha, Jay Beasley-Hall, Sabira Hasanoff, Timothy Barker, Danielle Pollock, Camille Schubert, Lynne Giles, Steve Vucic and 2 more

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurodegenerative disease management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cindy SternHealth Evidence Synthesis, Recommendations and Impact (HESRI), School of Public Health, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.ORCID 0000-0002-0924-5042
Ines SemendricHealth Evidence Synthesis, Recommendations and Impact (HESRI), School of Public Health, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.ORCID 0000-0002-7099-929X
Nipun ShresthaHealth Evidence Synthesis, Recommendations and Impact (HESRI), School of Public Health, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.ORCID 0000-0003-3542-8130
Jay Beasley-HallUniversity Library, The University of Adelaide, Adelaide, Australia.ORCID 0000-0001-8048-6319
Sabira HasanoffHealth Evidence Synthesis, Recommendations and Impact (HESRI), School of Public Health, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.ORCID 0000-0001-7246-0485
Timothy BarkerHealth Evidence Synthesis, Recommendations and Impact (HESRI), School of Public Health, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.ORCID 0000-0002-6897-814X
Danielle PollockHealth Evidence Synthesis, Recommendations and Impact (HESRI), School of Public Health, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.ORCID 0000-0002-6604-0609
Camille SchubertAdelaide Health Technology Assessment (AHTA), School of Public Health, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.ORCID 0000-0003-0828-1612
Lynne GilesSchool of Public Health, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.ORCID 0000-0001-9054-9088
Steve VucicBrain and Nerve Research Centre, Concord Clinical School, The University of Sydney, Sydney, Australia.
Tracy MerlinAdelaide Health Technology Assessment (AHTA), School of Public Health, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.ORCID 0000-0002-7293-4262
Zachary MunnHealth Evidence Synthesis, Recommendations and Impact (HESRI), School of Public Health, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.ORCID 0000-0002-7091-5842

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMotor Neurone Disease (MND) is a debilitating neurodegenerative condition affecting individuals, families, and carers. Evidence-informed care can improve outcomes, and guidelines play a key role in supporting this. A preliminary search showed limited guidelines exist, with none developed for the Australian context. This review aimed to identify existing health and social care guidelines for MND.

methodsA scoping review was conducted using Joanna Briggs Institute (JBI) methodology. Guidelines addressing health and social care for people with MND, gene carriers, family members, or carers were included regardless of publication status. Five databases and additional sources were searched. Two reviewers independently screened citations, and data were extracted and analysed descriptively, with qualitative content analysis grouping guideline questions. Reporting followed PRISMA-ScR.

resultsForty-two guidelines covering 133 questions were included. Most focused on symptom management for people with MND and were produced by professional bodies. Few used GRADE methodology or systematic reviews, and only seven assessed risk of bias. No guideline was developed for Australia.

conclusionsA high-quality, evidence-based MND guideline following best practice development methods is needed.

Indexed as

Motor Neuron DiseasePractice Guidelines as TopicAustraliaHumansamyotrophic lateral sclerosisguidelineLou Gehrig’s diseaseMotor Neurone Diseaseneurodegenerative diseases

Identifiers

PMID41178826
PMCPMC13596878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.