ArticleHippocampus2025
Manipulating Engram Histone Acetylation Alters Memory Consolidation.
Article in Hippocampus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- A computational framework for epigenetic plasticity in memory.Brain : a journal of neurology · 2026Review
- Writing the Engram: Epigenetic Mechanisms of Memory Allocation.Journal of neurochemistry · 2025Review
- Manipulating Engram Histone Acetylation Alters Memory Consolidation.Hippocampus · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The epigenome provides the brain with a nucleus-templated form of plasticity that is of fundamental importance for learning and memory. Of the various types of epigenetic modifications, elevations in histone acetylation have been shown to accompany learning and memory, yet the role this epigenetic modification plays within specific cell populations has remained unexplored. Here, we developed a genetic approach to manipulate whole-genome histone acetylation in memory-bearing neuronal ensembles. By showing that an increase in histone acetylation promotes fear memory recall, while its downregulation has the opposite effect, we revealed the existence of a functional relationship between histone acetylation and memory expression within memory-bearing engram cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.