Evidence map›Paper›PMID 41178759›Full record

ArticleHuman brain mapping2025

Cerebellar White Matter Microstructure Is Associated With Age, Cerebrospinal Fluid Amyloid Beta Levels, and Cognition in Cognitively Unimpaired Older Adults.

Elizabeth R Paitel, Corinne Pettigrew, Daniel D Callow, Abhay Moghekar, Michael I Miller, Andreia V Faria, Kenichi Oishi, Marilyn Albert, Anja Soldan

Abstract read
In one paragraph

Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elizabeth R PaitelDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-6507-0411
Corinne PettigrewDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Daniel D CallowDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Abhay MoghekarDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Michael I MillerDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Andreia V FariaDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-1673-002X
Kenichi OishiDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-1200-8611
Marilyn AlbertDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Anja SoldanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

Project 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI Abhay Moghekar · 2014 to 2026
$51.5M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
NIA NIH HHS P30 AG066507NIA NIH HHS P30-AG066507NIA NIH HHS T32-AG027668NIA NIH HHS U19 AG033655NIA NIH HHS U19-AG033655NIA NIH HHS U19-AG065169NIBIB NIH HHS P41 EB031771
6 · The paper itself

Abstract

Structural changes in the cerebellum contribute to cognitive decline due to aging and Alzheimer's disease (AD). However, it is unclear whether age and AD pathology are associated with structural alterations in the cerebellum among cognitively unimpaired individuals and how these alterations relate to cognition. This study examined the association of age and cerebrospinal fluid (CSF) AD biomarkers (amyloid beta [Aβ

Indexed as

AgingAmyloid beta-PeptidesCerebellumCognitionWhite MatterAdultAgedAged, 80 and overBiomarkersExecutive FunctionFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedAmyloid beta-PeptidesBiomarkersPeptide Fragmentstau ProteinsAlzheimer's diseaseamyloid betacerebellumcerebrospinal fluidcognitiondiffusion weighted imagingwhite matter microstructure

Identifiers

PMID41178759
PMCPMC12580907

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.