Evidence map›Paper›PMID 41178717›Full record

ArticleThe Journal of clinical investigation2025

Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome.

Kristy Tefft, Amy Wang, Zachary Z Reinstein, Yue Zhang, Arundhati Pillai, Sunghee Hwang, Spencer Ng, Raymond J Cho, Jeffrey B Cheng, Fei Li Kuang and 2 more

Abstract read
In one paragraph

Article in The Journal of clinical investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kristy TefftDepartment of Dermatology, Northwestern University, Chicago, Illinois, USA.
Amy WangDepartment of Dermatology, Northwestern University, Chicago, Illinois, USA.
Zachary Z ReinsteinDepartment of Dermatology, Northwestern University, Chicago, Illinois, USA.
Yue ZhangDepartment of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Arundhati PillaiDepartment of Dermatology, Northwestern University, Chicago, Illinois, USA.
Sunghee HwangDepartment of Dermatology, Northwestern University, Chicago, Illinois, USA.
Spencer NgDepartment of Dermatology, Northwestern University, Chicago, Illinois, USA.
Raymond J ChoDepartment of Dermatology, UCSF, San Francisco, California, USA.
Jeffrey B ChengDepartment of Dermatology, UCSF, San Francisco, California, USA.
Fei Li KuangDepartment of Allergy and Immunology, Northwestern University, Chicago, Illinois, USA.
Brett KingDermatology Physicians of Connecticut, Fairfield, Connecticut, USA.
Jaehyuk ChoiDepartment of Dermatology, Northwestern University, Chicago, Illinois, USA.

Funding

CARCINOGENESIS TRAINING PROGRAMT32CA009560 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1986 to 2026
$8.4M
Deciphering the roles of eosinophils and T lymphocytes in EGIDK23AI171085 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Fei Li Kuang · 2023 to 2026
$764k
CSRD VA I01 CX002608NCI NIH HHS T32 CA009560NIAID NIH HHS K23 AI171085
6 · The paper itself

Abstract

With cell-by-cell mapping, we charted immune cells in lymphocytic-variant hypereosinophilic syndrome, found drug targets, and showed targeted therapy removed disease-causing cells and eased symptoms.

Indexed as

Hypereosinophilic SyndromeT-LymphocytesAdultFemaleHumansMaleMiddle AgedPhenotypeDermatologyImmunologyLymphomasMolecular biologyT cells

Identifiers

PMID41178717
PMCPMC12578380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.