Evidence map›Paper›PMID 41178530›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Magnetoelectric Nanotherapy Achieves Complete Tumor Ablation and Prolonged Survival in Pancreatic Cancer Murine Models.

John Michael Bryant, Max Shotbolt, Emmanuel Stimphil, Victoria Andre, Elric Zhang, Veronica Estrella, Kazim Husain, Joseph Weygand, Doug Marchion, Alex Sebastian Lopez and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

John Michael BryantDepartment of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Max ShotboltCollege of Engineering, University of Miami, Coral Gables, FL, 33146, USA.
Emmanuel StimphilCancer Physiology/Clinical Science Laboratory, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Victoria AndreCollege of Engineering, University of Miami, Coral Gables, FL, 33146, USA.
Elric ZhangCollege of Engineering, University of Miami, Coral Gables, FL, 33146, USA.
Veronica EstrellaCancer Physiology/Clinical Science Laboratory, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Kazim HusainDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Joseph WeygandDepartment of Radiation Oncology and Applied Sciences, Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755, USA.
Doug MarchionTissue Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Alex Sebastian LopezTissue Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Dominique AbrahamsDepartment of Comparative Medicine, University of South Florida, Tampa, FL, 33612, USA.
Shawnus ChenCollege of Engineering, University of Miami, Coral Gables, FL, 33146, USA.
Mostafa Abdel-MottalebCollege of Engineering, University of Miami, Coral Gables, FL, 33146, USA.
Skye ConlanCollege of Engineering, University of Miami, Coral Gables, FL, 33146, USA.
Ibrahim OraiqatDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Vaseem KhatriDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Jose Alejandro GuevaraDepartment of Immuno-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Shari Pilon-ThomasDepartment of Immuno-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Gage RedlerDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Kujtim LatifiDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Natarajan RaghunandDepartment of Diagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Kosj YamoahDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Sarah HoffeDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
James CostelloDepartment of Diagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Jessica M FrakesDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Ping LiangCellular Nanomed Inc., Irvine, CA, 92617, USA.
Robert A GatenbyDepartment of Diagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Mokenge MalafaDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Sakhrat KhizroevCollege of Engineering, University of Miami, Coral Gables, FL, 33146, USA.ORCID https://orcid.org/0000-0002-4299-7094

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Defense Advanced Research Projects Agency N66001-19-C-4019National Science Foundation ECCS-211082NCI NIH HHS P30 CA076292NIH HHS 5P30 240139-02Radiological Society of North America (RSNA) RR232
6 · The paper itself

Abstract

Magnetoelectric nanoparticles (MENPs), when activated by a magnetic field, are shown to provide a minimally invasive, drug-free, theranostic approach to pancreatic ductal adenocarcinoma (PDAC) treatment. The magnetoelectric effect allows intravenously administered MENPs to be magnetically guided to PDAC tumors and remotely activated with a 7T-MRI field to induce targeted, electrode-free tumor ablation with real-time imaging feedback. A single MENP treatment achieved a threefold median reduction in tumor volume and complete tumor responses in 33.3% of mice at 300 and 600 µg doses (N = 17) and significantly longer mean overall survival as compared to the control cohorts (54.1 vs 28.8 days, χ

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsAnimalsCell Line, TumorDisease Models, AnimalFemaleHumansMagnetic Resonance ImagingMiceTheranostic Nanomedicinemagnetoelectric nanoparticlespancreatic cancertheranostics

Identifiers

PMID41178530
PMCPMC12904064

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.